Surface-Functionalized Conducting Nanofibers for Electrically Stimulated Neural Cell Function
نویسندگان
چکیده
Strategies involving the inclusion of cell-instructive chemical and topographical cues to smart biomaterials in combination with a suitable physical stimulus may be beneficial enhance nerve-regeneration rate. In this regard, we investigated surface functionalization poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV)-based electroconductive electrospun nanofibers coupled externally applied electrical for accelerated neuronal growth potential. addition, voltage-dependent conductive mechanism was studied depth interlink intrinsic properties electrically stimulated expressions. Surface accomplished using 3-aminopropyltriethoxysilane (APTES) 1,6-hexanediamine (HDA) as an alternative costly biomolecule coating (e.g., collagen) cell adhesion. The were uniform, porous, conductive, mechanically strong, stable under physiological conditions. amination boosted biocompatibility, 3T3 adhesion, spreading, while model rat PC12 line showed better differentiation on surface-functionalized mats compared nonfunctionalized mats. When stimulation (ES), these comparable or faster neurite formation elongation than collagen-coated no-ES findings indicate that ES provide improved strategy nerve regeneration MEH-PPV-based neural scaffolds.
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ژورنال
عنوان ژورنال: Biomacromolecules
سال: 2021
ISSN: ['1525-7797', '1526-4602']
DOI: https://doi.org/10.1021/acs.biomac.0c01445